https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46022 300 inflammatory genes were similarly regulated in the uterine endometrium by mating independently of paternal diet, and 13 were dysregulated by HFD-fed compared with CD-fed males. Seminal vesicle fluid factors reduced in HFD-fed males, including TGF-β1, IL-10, and TNF, were among the predicted upstream regulators of differentially regulated genes. Additionally, the T-cell response induced by mating with CD-fed males was blunted after mating with HFD-fed males, with 27% fewer CD4⁺ T cells, 26% fewer FOXP3⁺CD4⁺ regulatory T cells (Treg) cells, and 19% fewer CTLA4⁺ Treg cells, particularly within the NRP1⁺ thymic Treg cell population. These findings demonstrate that an obesogenic HFD alters the composition of seminal vesicle fluid and impairs seminal plasma capacity to elicit a favorable pro-tolerogenic immune response in females at conception.]]> Wed 09 Nov 2022 11:05:03 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48564 Tue 21 Mar 2023 15:51:48 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37678 Fri 12 Mar 2021 10:43:52 AEDT ]]>